%0 Journal Article
%T Design and in Vitro Biocompatibility of a Novel Ocular Drug Delivery Device
%A Nathan Gooch
%A Randon Michael Burr
%A Dolly J. Holt
%A Bruce Gale
%A Balamurali Ambati
%J Journal of Functional Biomaterials
%D 2013
%I MDPI AG
%R 10.3390/jfb4010014
%X The capsule drug ring (CDR) is a reservoir and delivery agent, which is designed to be placed within the capsular bag during cataract surgery. Prototypes were manufactured by hot melt extrusion of Bionate II £¿, a polycarbonate urethane. The devices have been optimized using Avastin £¿ as the drug of interest. In vitro biocompatibility was assessed with human lens epithelial cell (B-3), mouse macrophage (J774A.1) and mouse fibroblast (L-929) cell lines. Cell migration and proliferation were assessed after in vitro culture. Pro-inflammatory cytokines ( i.e., MIP-1¦Â, MIP-1¦Á, MCP-1, IL-1¦Â, TNF and TGF-¦Â1) were quantified using cytometric bead array (CBA). Preliminary in vivo biocompatibility and pharmacokinetics testing has been performed in rabbits.
%K CDR
%K capsular bag
%K drug delivery
%K biocompatibility
%U http://www.mdpi.com/2079-4983/4/1/14