%0 Journal Article
%T Development of New Therapeutic Strategies in Gynecological Cancers in Iran by Utilizing Xenograft Model of Ovarian Adenocarcinoma
%A Zohreh Mazaheri
%A Samad Muhammadnejad
%A Ahad Muhammadnejad
%A Moein Zargarzadeh
%J Journal of Family and Reproductive Health
%D 2010
%I Tehran University of Medical Sciences
%X Objective: To evaluate the potentiality of OVCAR¨C3 cell line of ovarian adenocarcinoma as a xenograft model for ovarian adenocarcinoma in nude mice.Materials and methods: The cell line isolated from advanced human ovarian adenocarcinoma, were inoculated to eight nude mice and two months later. Established tumors were transferred to pathologylaboratory to be prepared by H&E staining and immunohistochemical staining with CA125 antibody.Results: Study of H&E slides showed advanced adenocarcinoma. The CA125 Tumor marker was also positive in tumoral tissue.Conclusion: Established tumors showed excellently the characteristics of ovarian adenocarcinoma. This model can be used to evaluate new treatment strategies.
%K Gynecological Cancers
%K Xenograft Model
%K Ovarian Adenocarcinoma
%U http://journals.tums.ac.ir/upload_files/pdf/19057.pdf