%0 Journal Article
%T A Blinded Study Using Celecoxib for Prevention of Morphine Induced Pruritus in Patients Undergoing Cesarean Section
%A Saghar Samimi
%A Fatemeh Davari Tanha
%A Masume Malekian
%J Journal of Family and Reproductive Health
%D 2011
%I Tehran University of Medical Sciences
%X Objective: we aimed to evaluate the efficacy of celecoxib in reducing Intrathecal morphine-inducedpruritus in parturient undergoing cesarean section delivery under spinal anesthesia.Materials and methods: In a randomized double-blind placebo controlled study 126 women undergoing elective cesarean section under spinal anesthesia (0.5% bupivacaine 12mg plus 0.2 mg preservativefree morphine )were randomly allocated to receive celecoxib 400 mg or placebo, 2 hours prior to surgery. Severity of pruritus and pain score and frequency of opioid's side effects were recorded.Results: patients receiving celecoxib had significantly lower pruritus incidence and severity at 30 min,2,4 and 8 hours (40% versus 82%), but not at 12 and 24 hours postoperatively. Also there was a reduction in pain score but it was not significant (1.5¡À0.5 versus 1.9¡À0.65).Analgesic requirement was similar between two groups.Conclusion: Oral administration of celecoxib significantly reduced Intrathecal morphine-induced pruritusin parturient undergoing cesarean section under spinal anesthesia. There was no significant differencein pain scores and analgesic requirement.
%K IUD
%K Continuation Rate
%K Cause of Removal
%K Isfahan
%U http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/20097.pdf&manuscript_id=20097