%0 Journal Article
%T Prolonged GnRH suppression period in controlled ovarian hyperstimulation cycles: Impacts on IVF outcomes?
%A Ozlem Gun Eryilmaz
%A Esma Sarikaya
%A Leyla Mollamahmutoglu
%A Nedim Cicek
%J Iranian Journal of Reproductive Medicine
%D 2012
%I Shahid Sadoghi University of Medical Sciences of Yazd
%X Background: Prolonged GnRH-a administration in IVF cycles may have some advantages related to the treatment outcomes.Objective: In this study, we aimed to analyse the effect of prolonged gonadotropin releasing hormone agonist (GnRH-a) administration on controlled ovarian hyperstimulation outcomes of in vitro fertilization (IVF) patients.Materials and Methods: In this retrospective study, 55 patients with a GnRH-a administration period more than 10 days were compared with 55 patients whose same period was ¡Ü10 days with respect to the demographic characteristics, metaphase II (MII) oocyte ratio, grade I (GI) embryo ratio, blastocyst ratio, fertilization, implantation, and the clinical pregnancy rates.Results: The mean hospital visit count of the prolonged GnRH-a patients was 2.6¡À0.4. As we expected, total GnRH-a doses used during hypophyseal down regulation were significantly different between the groups (p<0.0001). MII oocyte, G1 embryo and the blastocyst ratios were also significantly different between the groups (p<0.0001; p<0.01 and p<0.05). All the other parameters were insignificant. Conclusion: Prolonged GnRH-a administration during ovarian suppression in IVF patients may have positive impacts on the oocytes and the embryos, but this affect may not be observed in the overall pregnancy rates.
%K GnRH agonist
%K IVF outcome
%K Embryo quality
%U http://www.ijrm.ir/library/upload/article/af_642979214)%2090-1-3%20(sh)%20okf.pdf