%0 Journal Article %T Prevalence and Complications of Drug-induced Seizures in Baharloo Hospital, Tehran, Iran %A Behnam Behnoush %A Fakhredin Taghadosinejad %A Mohammad Arefi %A Mohsen Shahabi %J Iranian Journal of Toxicology %D 2012 %I Arak University of Medical Sciences %X Background: Seizure is a frequent and important finding in the field of clinicaltoxicology. Almost all poisons and drugs can produce seizure. We have evaluatedfrequency and complications of drug-induced seizure in present study.Methods: The present descriptive cross-sectional study was done on patientswho were referred to Baharloo Hospital, Tehran, Iran, that had developed seizurebefore or after hospitalization following intoxication between 20 March 2010 and 20March 2011. The exclusion criteria were a positive history of epilepsy, headtrauma, or abnormal findings in EEG or brain CT scan.Results: Tramadol and tricyclic antidepressants were the most common causesof drug-induced seizure (31.5% and 14.7% of the cases, respectively). Overall, 6patients (4.2%) had developed persistent vegetative state in consequence of brainhypoxia, 16 patients (11.2%) had died due to complications of seizure or thepoisoning itself. Tramadol was the leading cause of drug-induced seizure and itsmorbidity and mortality. Tonic-colonic seizure was the most common type of druginducedseizure. Seizure had occurred once in 58% of the patients, twice in 37.1%of the patients, and had been revolutionized to status epilepticus in 4.9% of them.Among the 7 patients who had developed status epilepticus, 3 cases had died.Conclusion: Appropriate measures for treatment of seizure and prevention of itscomplications should be taken when patients with drug poisoning are admitted intohospital, especially when the offending drug(s) has a higher likelihood to induceseizure. %K Drug %K Iran %K poisoning %K seizure. %U http://www.yektaweb.com/~ijtoxic/browse.php?mag_id=11&slc_lang=en&sid=1