%0 Journal Article
%T The Effect of Nigerian Qua-iboe Brent Crude Oil on the Reproductive Performance of Female Wistar Albino Rats
%A A.N. Nwaigwe
%A K.O. Anya
%A C.O. Nwaigwe
%A C.U. Nwaigwe
%J Journal of Environmental Science and Technology
%D 2012
%I Asian Network for Scientific Information
%X The reproductive performance of rats given graded levels of the Nigerian Qua-Iboe brent crude oil was investigated in 32 female wistar albino rats. The experiment was divided into three parts, whereby, crude oil was given orally at the dose of 0.1, 0.2 and 0.4 mL, corresponding to Groups A, B and C, respectively, for four weeks, while the untreated group served as control (Group D). Experiment one investigated the effect of the crude oil on the oestrous cycle in rats divided into four groups of four replicates, monitored for four consecutive cycles for regularity of oestrous cycle using vaginal cytology. Three of the four groups were drenched with graded levels of the crude oil while remaining group served as the control. Experiment two investigated the effect of crude oil on gestation, using another set of female Wistar albino rats which were grouped and drenched as in experiment one. Mating was monogamous, while drenching done every other day following mating. The gestation length, litter size, stillbirth and gross malformation of foetuses were monitored. The same group of animals in experiment two was used for experiment three, whereby the animals were drenched prior to mating and until parturition. Results showed irregularity of oestrous cycle in the drenched groups, with significant differences (p<0.05) existing between the experimental group and control group considering stillbirths, conception rates, gestation length and litter size. These findings suggested that exposure to Nigerian Qua-Iboe Brent crude oil affected the reproductive performance of the rats.
%K Oestrous cycle
%K gestation length
%K mating oral administration
%K vaginal cytology
%K still birth
%U http://docsdrive.com/pdfs/ansinet/jest/2012/84-90.pdf