%0 Journal Article
%T Comparing intramuscular progesterone, vaginal progesterone and 17  -hydroxyprogestrone caproate in IVF and ICSI cycle
%A Ashraf Moini
%A Fatemeh Zafarani
%A Bita Eslami
%A Maria Sadeghi
%J Iranian Journal of Reproductive Medicine
%D 2011
%I Shahid Sadoghi University of Medical Sciences of Yazd
%X Background: Supplementation of luteal phase with progesterone is prescribed for women undergoing routine IVF treatment.Objective: The objective of this study was to compare the efficacy of three types of progesterone on biochemical, clinical and ongoing pregnancy rates and abortion and live birth rates.Materials and Methods: A prospective randomized study was performed at Royan Institute between March 2008 and March 2009 in women under 40 years old, who use GnRH analog down-regulation. One hundred eighty six patients in three groups were received progesterone in oil (100 mg, IM daily), intravaginal progesterone (400 mg, twice daily) and 17-  hydroxyprogestrone caproate (375mg, every three days), respectively.Results: Final statistical analysis after withdrawal of some patients was performed in 50, 50 and 53 patients in group 1, 2 and 3 respectively. No differences between the groups were found in baseline characteristics. No statistical significance different was discovered for biochemical, clinical and ongoing pregnancies. Although the abortion rate was statistically higher in group 1 (p=0.025) the live birth rate was not statistically significant between the three groups.Conclusion: The effects of three types of progesterone were similar on pregnancies rate. We suggest the use of intravaginal progesterone during the luteal phase in patients undergoing an IVF-ET program because of the low numbers of abortions, and high ongoing pregnancy rates
%K In vitro fertilization
%K Luteal phase
%K Progesterone
%K Pregnancy
%U http://www.ijrm.ir/library/upload/article/af_392233610)%2089-25-3F.pdf