%0 Journal Article
%T Serum levels of TNF-¦Á and osteoprotegerin and bone mineral density in patients with Beh et¡¯s Disease
%A Ali Kutlucan
%A Sevket Ercan Tunc
%A Davut Baltac£¿
%A Mehmet Sahin
%J Dicle Medical Journal
%D 2012
%I Dicle University Medical School
%X Objectives: Osteoporosis is commonly developed due tonatural course of Beh et¡¯s disease (BD) and therapeuticagents. It was aimed to investigate levels of osteoprotegerinand TNF-¦Á (tumor necrosis factor), and bone mineral density(BMD) and correlation between them in BD.Materials and methods: The study included two groupsas the study and the control group. Serum levels of TNF-¦Á,osteoprotegerin, osteocalcine, erythrocyte sedimentation rate(ESR), C-reactive protein (CRP), and urinary creatinine anddeoxypyridinoline along with BMD level were evaluated andcompared. Correlation between TNF-¦Á and osteoprotegerinlevel was investigated.Results: The study enrolled 41 BD patients and 36 agedmatchedcontrol subjects. Mean age was 42.26¡À11.64 and41.66¡À70.99, in the study and control groups, respectively.There was no significant difference in body mass index(BMI) of subjects between groups (p>0.05). Level of TNF-¦Á(p<0.001), deoxypyridinoline (p<0.001) and osteocalcine(p=0.041) was significantly higher in the study group comparedto the control group. Osteoprotegerin was lower inBD patients, but the difference was not significant (p>0.05).Urinary deoxypyridinoline/ urinary creatinine ratio in patientswith BD was significantly higher than those in control group(p=0.030). Patients had significantly lower BMD comparfedto the control group, except L2-L4 vertebral area (p<0.001,p<0.001, p=0.035, p<0.001, p=0.012, p<0.001, p<0.001 andp=0.111, respectively). No correlation was found betweenTNF-¦Á and osteoprotegerin.Conclusions: The present study indicated that TNF-¦Á andBMD was negatively correlated with each other and TNF-¦Áhad an effect on osteoporotic process in patients with BD.Osteoprotegerin level was not decreased, and not correlatedwith TNF-¦Á.Key words: Beh et¡¯s disease, osteoprotegerin, TNF-¦Á, osteocalcine
%K Beh et¡¯s disease
%K osteoprotegerin
%K TNF-¦Á
%K osteocalcine
%U http://diclemedj.org/upload/sayi/3/Dicle%20Med%20J-01214.pdf