%0 Journal Article
%T The comparison of early and late effectiveness of systemic and high dose inhaled glucocorticoids in the management of acute asthma attacks in children
%A ¨¹nal Uluca
%A £¿zlem Keskin
%A B¨¹lent G£¿gebakan
%A Sinan Balaban
%J Dicle Medical Journal
%D 2013
%I Dicle University Medical School
%X Objective: In this study it was aimed to compare effectivenessof systemic steroids and inhaled corticosteroids inchildren who applied with acute asthmatic attack.Materials and methods: Children with acute asthmatic attackwere randomly allocated to two groups; 1 mg/kg peroral methylprednisolone was given to Group 1 (Systemicsteroid group, n=27), and 4000 ¦Ìg inhaled fluticasone toGroup 2 (Inhaled steroid group, n=35). Following treatmentpatients were evaluated for four hours, at one-hourintervals by asthma score, forced expiratory volume infirst-second (FEV1) and peak expiratory flow (PEF). Primaryoutcome of this study was the rate of hospital admissionsand secondary outcome were asthma score, FEV1,PEF and oxygen saturation.Results: Significant improvements were obtained in measuredparameters in both Group 1 and Group 2. Values ofmeasured parameters at hospital admission, 4th hour oftreatment and while patients were in comfort were as follow:PEF values (Group 1: 173, 223, 220 L/min, p <0.001):Group 2 113, 141 , 192 L/min, p <0.001); FEV 1 (Group1: 74.9%, 89.5%, 85.6%, p <0.0001; Group 2: 96, 89.8,93.2 %, p <0.0001); O2 saturation (Group 1:93.2%, 95.6%,96.8%, p <0.0001, Group 2: 93%, 95.2%, 96.6%, p<0.001);and asthma score (Group 1: 9.4, 6.6, 5.7, p<0.001, Group2: 9.3, 6.8, 6.5, p<0.001). In all measured parameterssignificant improvements were observed with treatmentmodalities within both groups. No significant differenceswere found in all parameters between Group 1 and Group2 (p>0.05).Conclusion: No significant differences were found in asthmascore, FEV 1 and PEF parameters between systemichigh-dose methylprednisolone and inhaled fluticasonetreatment modalities in acute asthmatic attacks of children.Key words: Asthma, asthma exacerbation, inhaled fluticasone,systemic corticosteroid
%K Key words: Asthma
%K asthma exacerbation
%K inhaled fluticasone
%K systemic corticosteroid
%U http://www.diclemedj.org/upload/sayi/26/Dicle%20Med%20J-01613.pdf