%0 Journal Article
%T Evaluation of interleukin-2 and tumor necrosis factor-¦Á levels in patients with lichen
%A Derya U£¿mak
%A G£¿k£¿en Balc£¿
%A Mehmet Harman
%J Dicle Medical Journal
%D 2012
%I Dicle University Medical School
%X Objectives: Lichen planus is an immunologic diseasemediated by lymphocytes in which T lymphocytes targetat basal cells. It is believed that TNF-¦Á that is releasedfrom T lymphocytes and keratinocytes plays a key role inthe starting and progression of lichen planus by inducingapoptosis. MHC Class-I antigens on basal keratinocytesand interleukin-2 (IL-2) and IFN-gamma (¦Ã) that are producedfrom CD4+ T cells stimulate the apoptosis of keratinocytesin lichen planus. The aim of this study was tomeasured the IL-2 and TNF-¦Á levels in peripheral bloodfrom patients with Lichen planus.Materials and methods: A total of 26 lichen planus patients(18 females, 8 males) that applied to the dermatologypoliclinics in Dicle University Hosspital between 2004and 2006 and a healthy control group were included inthe study. Serum IL-2 and TNF-¦Á levels were measuredby using Immulate 1000 solid phase and two-site chemiluminescentimmunometric assay method. The results ofpatients and control group were compared.Results: Level of IL-2 (1172.615 ¡À 774.967) and TNF-¦Á(13.361 ¡À 5.638) were higher in lichen planus to comparedcontrols. IL-2 and TNF-¦Á levels in the patient group werefound to be significantly high statistically compared tohealth control group, respectively p=0.004 and p<0.001.Conclusion: The high levels of IL-2 and TNF-¦Á in lichenplanus patients support the role of immunity in the pathogenesisof the disease
%K Lichen planus
%K IL-2
%K TNF-¦Á
%U http://www.diclemedj.org/upload/sayi/1/DicleMedJ-01080.pdf