%0 Journal Article
%T Serum Cortisol Levels as a Predictor of Neurologic Survival inSuccessfully Resuscitated Victims of Cardiopulmonary Arrest
%A Nader Tavakoli
%A Ali Bidari
%A Samad Shams Vahdati
%J Journal of Cardiovascular and Thoracic Research
%D 2012
%I Tabriz University of Medical Sciences
%X Introduction: Out-of-hospital cardiac arrest (OHCA) is the most stressful lifetime event for the victims and an important issue for the emergency physicians. The status of the hypothalamic pituitary- adrenal axis (HPA) function in successfully resuscitated victims of cardiopulmonary arrest has been recently of an interest for the researchers. Methods: In a prospective cohort study, 50 successfully resuscitated OHCA victims¡¯ serum cortisol levels were measured 5 minutes and 1 hour after return of spontaneous circulation (ROSC). The data were analyzed comparing the one-week neurologic survival. Results: Fifty blood samples were obtained for serum cortisol levels after 5 minutes of ROSC. Fourteen patients (28%) pronounced death during one hour after CPR. Blood sample from living 36 patients after one hour post-CPR were obtained for second cortisol assay. Eleven patients (22%) were neurologically survived after one week. Seven patients (14%) were discharged finally from hospital with good neurologic recovery. The serum cortisol levels in both the neurologically surviving and the non-surviving after 5 minutes of ROSC patients were 63.4 ¡À13.6 and 43.2¡À25.5(microg/ml), (mean¡ÀS.D., respectively) and after 1 hour of ROSC patients¡¯ serum cortisol levels were 64.9¡À13.1 and 47.3¡À27.1(microg/ml), (mean¡ÀS.D., respectively). The difference was significantly higher in neurologically survived group in both 5 minutes and 1 hour after ROSC (P= 0.015 and 0.013 respectively). Conclusion: serum cortisol levels after 5 minutes and one hour of ROSC in victims of cardiopulmonary arrest are significantly higher in neurologically survived than non-survived patients.
%K Cardiopulmonary Arrest
%K Cortisol Level
%K Neurologic Outcome
%U http://dx.doi.org/ 10.5681/jcvtr.2012.026