%0 Journal Article
%T A rare chest wall localized soft tissue sarcoma: Clear cell sarcoma
%A Ula£¿ Alabal£¿k
%A Ay£¿e Nur Kele£¿
%A H¨¹seyin B¨¹y¨¹kbayram
%A U£¿ur F£¿rat
%J Dicle Medical Journal
%D 2013
%I Dicle University Medical School
%X The clear cell sarcomas of soft tissue are rare tumorsoriginating from neural crest cells and presenting withpoor prognosis. By the reason of the resemblance ofhistological properties to malign melanoma (eg. the immunoreactivityto S100 and HMB45, the presence of melanosomesultrastructurally), these tumors are also definedas malign melanomas of soft tissue. But distinctivelyfrom cutaneous melanoma, clear cell sarcoma is almostalways deeply localized and the biological behaviour ofthe last one is also different. The differential diagnosisbetween clear cell sarcoma and desmoplastic or spindlecell malign melanoma may be more difficult because ofthe dermal localization of the last ones. In our case, itwas observed an infiltrative tumor composed of uniformseeming cells with vesicular nuclei, distinct nucleoli, paleeosinophilic and sometimes clear, scant cytoplasms, inaddition to necrotic areas. On immunohistochemical examination,the tumoral cells showed a positive immunoreactivityto vimentin, S100, HMB45, and SMA, while showingnegative immunoreactivity with CD34, PanCK, EMA,LCA, CD99 and desmin. Ki-67 proliferation index was determinedas approximately 50%. Because of deep localizationand different morphological-immunohistochemicalfindings of the tumor, the case was diagnosed as ¡°clearcell sarcoma¡±. It was observed a tumor with similar morphologyin the biopsy sample taken from vertebra of thepatient one month later than the first material and this wascommented as the metastasis of the tumor to vertebra.Key words: Clear cell sarcoma, chest wall, metastasis,vertebral, HMB-45, S-100
%K Key words: Clear cell sarcoma
%K chest wall
%K metastasis
%K vertebral
%K HMB-45
%K S-100
%U http://www.diclemedj.org/upload/sayi/26/Dicle%20Med%20J-01035.pdf