%0 Journal Article
%T Effects of Administration of Alpha-melanocyte Stimulating Hormone (a-MSH) on the Content of Corticosterone in Some Tissues of Alloxan-induced Diabetic Rats
%A Kamal Mohmoud Saleh Mansi
%J International Journal of Zoological Research
%D 2007
%I Academic Journals Inc.
%X This study was designed to evaluate the role of alpha-melanocyte stimulating hormone (a-MSH) on the content of corticosterone in some tissues of alloxan induced diabetic rats. Forty male white rats were divided into four experimental groups: control, diabetic, a-MSH-treated and a-MSH-treated diabetic. At the end of the experimental period (3 weeks), animals in all four groups were fasted for 12 h and blood samples were taken for the determination of plasma insulin, corticosterone, ACTH, glucose levels and concentration of corticosterone in various tissues of diabetic rats as kidney, hypothalamus, liver, adrenal gland, cerebral, hemisphere and thyroid gland. It was found that at the end of the experiment the insulin concentration in blood progress in decreasing reaching the value (0.680.07 mU L-1) on the 10 th day after introducing of alloxan in comparison with the control (1.8430.423 mU L-1), blood glucose level increased and reached (11.521.34 mole L-1) and still higher than control and other groups and the plasma concentrations of ACTH (158.536.45 pmol L-1) in diabetic group and (84.533.94 pmol L-1) in a-MSH-treated diabetic compared with the control (63.845.52 pmol L-1) and a-MSH-treated (58.364.81 pmol L-1). Corticosterone level was increased in diabetic group (7.1641.54 ng mL-1) and in a-MSH-treated diabetic (9.641.68 ng mL-1) compared with the control (1.640.342 ng mL-1) and a-MSH-treated (2.870.418 ng mL-1). After the analysis and measuring the content of corticosterone in various tissues of diabetic rats it was found that alloxan decreased the corticosterone level in all selected tissues and after the injection of a-MSH the content of corticosterone increased in tissues compared with diabetic group and still lower than control and a-MSH-treated. It is concluded that exogenous introduction of (a-MSH) in alloxan-induced diabetic rats increased the concentration of the total plasma level of corticosteron, at the same time decreased the content of corticosterone occurs adrenal gland, hemisphere and increased it in hypothalamus, kidney, liver and thyroid gland.
%K Alloxan
%K diabetic mellitus
%K a-MSH
%K corticosterone
%K ACTH
%K HPA
%K hypothalamus
%U http://docsdrive.com/pdfs/academicjournals/ijzr/2007/33-40.pdf