%0 Journal Article
%T Benign intracranial hypertension associated to blood coagulation derangements
%A Domenico De Lucia
%A Marisanta Napolitano
%A Pierpaolo Di Micco
%A Alferio Niglio
%A Andrea Fontanella
%A Giuseppe Di lorio
%J Thrombosis Journal
%D 2006
%I BioMed Central
%R 10.1186/1477-9560-4-21
%X The incidence of prothrombotic abnormalities among a randomly investigated cohort of 17 patients with BIH, was compared with 51 healthy subjects matched for sex, age, body mass index, height and social background.The number of subjects with protein C deficiency was significantly higher in patients than in controls (3 vs 1, p < .001; Fisher Exact Test). Moderate to high titers of anticardiolipin antibodies (¦Â2-Glycoprotein type I) were found in 8 out of 17 patients.Increased plasma levels of prothrombin fragment 1+2, fibrinopeptide A (FPA), and PAI-1 were demonstrated in patients group (5.7 ¡À 1.15 nM vs 0.45 ¡À 0.35 nM; 8.7 ¡À 2.5 ng/mL vs 2.2 ¡À 1.25 ng/mL; 45.7 ¡À 12.5 ng/mL vs 8.5 ¡À 6.7 ng/mL, respectively; p < .001; Fisher Exact Test). Gene polymorphisms for factor V Leiden mutation, prothrombin mutation 20210 A/G, MTHFR 677 C/T, PAI-1 4G/5G, ACE I/D were detected in 13 patients.In agreement with other authors our data suggest a state of hypercoagulability in BIH associated with gene polymorphisms. Our findings also showed that mutations in cardiovascular genes significantly discriminate subjects with a BIH history. The association between coagulation and gene derangements, usually regarded to as cryptogenic, may suggest a possible pathogenetic mechanism in BIH. So, a prothrombotic tendency may exist that would, at least in part, explain some cases of BIH.Although based on a small population, these findings raise the exciting possibility of using these haemostatic factors as markers for selecting high-risk subjects in BIH disease.Benign Intracranial Hypertension (BIH) is due to an increased intracranial pressure of unknown origin [1]. One of the possible causes of BIH may be due to intracranial venous sinus thrombosis [2], although cerebral angiograms could be normal in patients affected by BIH associated with conditions highly predisposing to venous thrombosis. This raises the possibility that unrecognised non-occlusive venous thrombus might impede cerebral spinal f
%U http://www.thrombosisjournal.com/content/4/1/21