%0 Journal Article
%T VALIDATED SPECTROPHOTOMETRIC METHODS FOR SIMULTANEOUS ESTIMATION OF METRONIDAZOLE AND FURAZOLIDONE IN PURE AND IN TABLET DOSAGE FORM
%A Chemate Satyam Z.
%A Dongare Umesh S.
%A Jadhav Shweta A.
%A Jadhav Manisha B.
%J International Research Journal of Pharmacy
%D 2012
%I International Research Journal of Pharmacy
%X Two methods are developed for simultaneous estimation of metronidazole and furazolidone in pure and in tablet dosage form by using distilled water as a solvent. Quantitation was carried out by the proposed methods namely simultaneous equation (Method I) and absorbance ratio (Method II). The wavelengths selected for Method I were 320.2 nm and 367.0 nm i.e. the respective ¦Ëmax of both the drugs. In Method II two wavelengths 352.4 nm, the isobestic point and 320.2 nm ¦Ëmax of metronidazole were selected. Both the drugs obey Beer¡¯s law in the range of 5-30 ¦Ìg/ml for metronidazole and 5-50 ¦Ìg/ml for furazolidone. The methods are simple, rapid, accurate, precise, reproducible, and economic and can be used for routine quantitative analysis of metronidazole and furazolidone in pure and in tablet dosage form.
%K Metronidazole
%K Furazolidone
%K Beer¡¯s law
%K Simultaneous equation method
%K Absorbance ratio method
%K Validation.
%U http://www.irjponline.com/admin/php/uploads/1148_pdf.pdf