%0 Journal Article
%T SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF AMBROXOL HYDROCHLORIDE, LEVOCETIRIZINE DIHYDROCHLORIDE AND PHENYLEPHRINE HYDROCHLORIDE IN TABLET DOSAGE FORM
%A Ghodasara Rahul B
%A Prajapati Arun M
%J International Research Journal of Pharmacy
%D 2013
%I International Research Journal of Pharmacy
%X The present manuscript describes simple, sensitive, rapid, accurate, precise and economical spectrophotometric method for the simultaneous determination of ambroxol hydrochloride, levocetirizine dihydrochloride and phenylephrine hydrochloride in bulk and tablet dosage form. The method is based on the simultaneous equations for analysis of the three drugs using methanol as solvent. Ambroxol hydrochloride has absorbance maxima at 248 nm, levocetirizine dihydrochloride has absorbance maxima at 230 nm and phenylephrine hydrochloride has absorbance maxima at 217 nm in methanol. The linearity was obtained in the concentration range of 5-35 ¦Ìg/ml, 4-28 ¦Ìg/ml and 2-28 ¦Ìg/ml for ambroxol hydrochloride, levocetirizine dihydrochloride and phenylephrine hydrochloride, respectively. The concentrations of the drugs were determined by using simultaneous equations at three wavelengths. The mean recovery was 101.41 ¡À 0.82, 99.09 ¡À 0.95 and 99.52 ¡À 1.59 for ambroxol hydrochloride, levocetirizine dihydrochloride and phenylephrine hydrochloride, respectively. The method was successfully applied to combined dosage form because no interference from the excipients was found. The suitability of this method for the quantitative determination of ambroxol hydrochloride, levocetirizine dihydrochloride and phenylephrine hydrochloride was proved by validation. The proposed method was found to be simple and sensitive for the routine quality control application of ambroxol hydrochloride, levocetirizine dihydrochloride and phenylephrine hydrochloride in combination. The results of analysis have been validated statistically and by recovery studies.
%K Ambroxol hydrochloride
%K Levocetirizine dihydrochloride
%K Phenylephrine hydrochloride
%K Recovery
%K Simultaneous equations method
%K Validation.
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