%0 Journal Article
%T STABILITY STUDY OF STAVUDINE SINTERED MATRIX TABLET
%A Vaibhav Bhamre
%A Dipika Sherkar
%A Dilip Derle
%A Minal Narkhede
%J International Research Journal of Pharmacy
%D 2013
%I International Research Journal of Pharmacy
%X Stavudine has half life (t1/2) 1.5 hours; therefore it needs to be frequently administered during therapy which gives patient incompliance. In this study attempt has been done to study effect of three different storage conditions on stability of Stavudine sintered matrix tablet. Tablets were prepared using combination of Eudragit RS 100 (22 - 33 %w/w) and Compritol 888 ATO (9-13 %w/w) by direct compression. The prepared tablets were sintered using 400 c temperature for time period of 4 hrs. Prepared Stavudine sintered matrix tablets are then exposed to refrigerated condition, room temperature and elevated temperature of 600C for stability study. The unsintered and sintered tablets were evaluated by organoleptic evaluation, drug content, drug release; percent water uptake and percent matrix erosion. Comparison is made in between results of evaluation parameters of unsintered and sintered formulations. It was evident that different storage conditions for identical formulation significantly impact the release profile of drug.
%K Stavudine Sintered Matrix Tablet
%K Refrigerated Temperature
%K Room Temperature
%K Elevated Temperature.
%U http://www.irjponline.com/admin/php/uploads/1592_pdf.pdf