%0 Journal Article
%T Divalproex Sodium and Topiramate for Migraine Prophylaxis
%A Y£¿ld£¿z De£¿irmenci
%A Erkan Karag£¿z
%A Handan £¿z£¿£¿£¿k Karaman
%J Journal of Clinical and Analytical Medicine
%D 2012
%I Derman Medical Publishing
%R 10.4328
%X Aim: To compare the efficacy, safety of topiramate and extended-release divalproex sodium in migraine prophylaxis. Material and Method: Study groups consisted of 22 patients with chronic migraine, randomly administered 1000 mg extended-release divalproex sodium (first group), 21 patients given 100 mg topiramate (second group).Study was 28-week randomized, prospective trial including 4-week baseline, 4-week titration, 20-week maintenance phase.Primary efficacy measure was reduction from baseline in 4-week migraine frequency.Secondary efficacy measures included responder rates, mean reduction in migraine duration,severity.Severity of headache was quantified by using 10-point visual analogue scale (VAS). Responder rates were defined as percentage of patients who demonstrated ¡Ý 50%. reduction in migraine frequency per month. Results: Reduction from baseline migraine frequency at the end of six month was primary outcome measure.Mean migraine frequency at the end of study was 1.27 ¡À 1 (baseline; mean ¡À SD: 3.6 ¡À 2) in the first, 1.2 ¡À 1.2 (baseline; mean ¡À SD: 3.5 ¡À 2.3) (p<0.0001) in the second group.Significant improvement in frequency was observed in 16 patients (72.7%) in the first group, and 16 patients (76.2%) in the second group.Only a limited number of patients were excluded from the study due to side effects as 2 patients from the first group and 1 patient from the second group.The most common side effect was weight gain in the first and paresthesia in the second group. Discussion: Both divalproex sodium, topiramate were almost equally effective in reducing migraine frequency, duration, severity.Total relief from migraine attacks were more in topiramate than extended-release divalproex sodium.
%K Extended-Release Divalproex Sodium
%K Topiramate
%K Migraine Prophylaxis
%U http://www.jcam.com.tr/files/KATD-724.pdf