%0 Journal Article
%T Association of serum immunoglobulin G (IgG) levels against two periodontal pathogens and prothrombotic state: a clinical pilot study
%A Sergio Bizzarro
%A Elena A Nicu
%A Ubele van der Velden
%A Marja L Laine
%A Bruno G Loos
%J Thrombosis Journal
%D 2010
%I BioMed Central
%R 10.1186/1477-9560-8-16
%X Patients with moderate (n = 38) and severe periodontitis (n = 30) and controls (n = 24) were recruited. We explored correlations between serum anti-Aa and anti-Pg IgG and plasma levels of markers of prothrombotic state (von Willebrand Factor [vWF], prothrombin fragment 1+2 [F1+2], plasminogen activator inhibitor-1 [PAI-1] and D-dimer). Multivariate analyses were performed considering several major potential contributing factors.Periodontitis patients showed higher anti-Aa IgG (p = 0.015) than controls but not for Pg (p = 0.320). In periodontitis patients, body mass index and anti-Aa IgG showed a positive correlation with vWF (¦Â = 0.297, p = 0.010 and ¦Â = 0.248, p = 0.033 respectively).In periodontitis, infection with Aa together with other well accepted risk factors for CVD, may play a role in increasing the risk for prothrombotic state.Periodontitis is a chronic infectious disease of the supporting tissues of the teeth and it has been consistently associated with cardiovascular diseases (CVD) [1,2]. One explanation in this association is that periodontitis may also cause a prothrombotic state [3-7]. The prothrombotic state is a propensity of blood to coagulate due to an abnormality in the coagulation and/or fibrinolysis system. In our previous study we measured well established markers of a prothrombotic state which are risk indicators for vascular ischemic events. Prothrombin factor 1+2 (F1+2) is a peptide released during the conversion of prothrombin into thrombin, which is the final step of the coagulation cascade (extrinsic pathway). Von Willebrand Factor (vWF) is expressed by endothelial cells after tissue damage and it triggers aggregation of platelets. Furthermore, vWF is involved in coagulation since it carries the factor VII of the coagulation cascade. Plasminogen activator inhibitor-1 (PAI-1) is an important inhibitor of fibrinolysis and D-dimer is a polymer released during the dissolution of the fibrin clot during fibrinolysis. In our previous study we o
%U http://www.thrombosisjournal.com/content/8/1/16