%0 Journal Article
%T Hereditary thrombophilia
%A Salwa Khan
%A Joseph D Dickerman
%J Thrombosis Journal
%D 2006
%I BioMed Central
%R 10.1186/1477-9560-4-15
%X Thrombophilia can be defined as a predisposition to form clots inappropriately. Thrombotic events are increasingly recognized as a significant source of mortality and morbidity [1]. The predisposition to form clots can arise from genetic factors, acquired changes in the clotting mechanism, or, more commonly, an interaction between genetic and acquired factors [2]. A hereditary thrombophilia results when an inherited factor, such as antithrombin or protein C deficiency, requires interaction with components that are inherited or acquired before onset of a clinical disorder [3]. A homozygous abnormality or combination of two or more heterozygous abnormal factors can lead to clinically apparent thrombotic disorders at an early age. However, milder heterozygous traits, when existing alone, are more often discovered by laboratory investigation. [3]. Since the turn of the last century, there has been extensive research focusing on both the genetic and acquired causes of thrombophilia, with particular focus on clotting events in the venous circulation. This paper will focus on clinically relevant aspects of genetic venous thrombophilia. While there is evidence for adverse outcomes of pregnancy associated with thrombophilia, an in-depth discussion of that area is beyond the scope of this article.In 1856, Rudolf Virchow proposed a hypothesis to explain the etiology of pulmonary emboli, which lead to the understanding of the three primary causes of venous and arterial thrombosis: stasis, injury to the vessel wall and abnormalities in the circulating blood. Subsequently, numerous investigators elucidated the concept of a hemostatic balance between fibrin formation and fibrin dissolution.As our insight into the hemostatic and fibrinolytic pathways has developed it has become apparent that there are specific factors that can create an imbalance in the clotting process and thus lead to thrombosis as originally suggested by Virchow. An understanding of both the coagulation and fibr
%U http://www.thrombosisjournal.com/content/4/1/15