%0 Journal Article
%T Melanosis of the vagina and human papillomavirus infection, an uncommon pathology: Case Report Melanosis de la vagina e infecci車n por virus del papiloma humano, una patolog赤a poco com迆n: Reporte de un Caso
%A Jos谷 N迆ˋez-Troconis
%A Mariela Delgado
%A Gerardo Gonz芍lez
%A Airiaudis Rivas
%J Investigaci車n Cl赤nica
%D 2011
%I Scientific Electronic Library Online
%X Benign melanotic lesions of the vagina are uncommon and only a few cases have been reported in the literature. A 34-year-old woman was referred because of a Vaginal Intraepithelial Neoplasia 1 biopsy result. On the gynecological examination, two different hyperpigmented areas were noted in the vagina. The colposcopic visualization of the cervix and vagina found an aceto-white lesion at the right lateral wall of the upper third of the vagina. Biopsies from three areas were taken. Histological study reported a melanosis of the vagina and HPV infection. An immunohistochemical panel of epithelial markers was performed in vaginal samples, such as Cytokeratin AE1/AE3 and epithelial membrane antigen, mesenchymal marker: vimentin; melanocytic makers: protein S-100 and HMB45 (Human Melanoma Black); proliferating cell marker: proliferating cell nuclear antigen (PCNA), and P-53 oncoprotein. High Risk (16, 18, 31, 45) and Low Risk (6, 11) HPV types were studied by In Situ Hybridization using the same vaginal samples. CK, EMA and Vimentin were 2+. Melanocytic markers, HMB45 and S100, and PCNA were 1+ in basal cell layer. P-53 was negative. The melanotic tissue and acetowhite lesion were positives to HPV Types 6,11. In conclusion, melanosis of the vagina is a uncommon benign pathology. Usually, melanosis is present in women over 40 years old. We present a case of melanosis of the vagina in a young woman infected with low-risk HPV types and review the literature. Las lesiones melan車ticas de la vagina son infrecuentes. y Solo pocos casos han sido reportados. Se presenta el caso de una mujer de 34 a os quien es referida con diagn車stico de una Neoplasia Intraepitelial Vaginal 1. Al examen ginecol車gico, se encontraron dos 芍reas hiperpigmentadas en la vagina. La exploraci車n colposc車pica del cuello uterino y vagina revel車 la presencia de una lesi車n aceto-blanca en la pared lateral derecha del tercio superior de la vagina. Muestras de biopsias fueron tomadas en dichas 芍reas. El estudio histol車gico report車 una melanosis de la vagina y una infecci車n por el virus del Papiloma Humano (VPH). Se realiz車 un panel de estudio inmunohistoqu赤mico de marcadores epiteliales en las muestras vaginales: tales como citoqueratina AE1/AE3 y ant赤geno epitelial de membrana; marcador mesenquimal: vimentin; marcadores melan車ticos: proteina S-100 y HMB45 (Human Melanoma Black); marcadores de proliferaci車n celular: ant赤geno de proliferaci車n nuclear (PCNA), y la oncoprote赤na P-53. Se realiz車 Hibridizaci車n In Situ para establecer los tipos de alto (16, 18, 31, 45) y bajo (6, 11) riesgo de VPH en las m
%K Melanosis
%K virus del papiloma humano
%K patolog赤a vaginal
%K Melanosis
%K human papillomavirus
%K vaginal pathology
%U http://wwww.scielo.org.ve/scielo.php?script=sci_arttext&pid=S0535-51332011000300008