%0 Journal Article
%T Update on red blood cell alloimmunization in sickle cell disease and in thalassemia
%A A. Matteocci
%J Drugs and Cell Therapies in Hematology
%D 2012
%I PAGEPress Publications
%R 10.4081/dcth.2012.1s.52
%X Repetitive red blood cell (RBC) transfusions are the main supportive treatment in sickle cell disease (SCD) and thalassemia patients. Blood transfusion is a life-sustaining therapy for these patients, but it has side-effects such as iron overload and alloimmunization. RBC alloimmunization remains a major challenge of chronic transfusion therapy and occurs when the immune system is exposed to foreign antigens that are different from its own...
%U http://www.dcth.org/dcth/article/view/13