%0 Journal Article
%T Bariatric surgery and T2DM improvement mechanisms: a mathematical model
%A Puntip Toghaw
%A Alice Matone
%A Yongwimon Lenbury
%A Andrea De Gaetano
%J Theoretical Biology and Medical Modelling
%D 2012
%I BioMed Central
%R 10.1186/1742-4682-9-16
%X The modeling results seem to indicate that the suppression of ghrelin release is unlikely to determine major changes in short-term glucose control. The possible existence of an anti-incretin hormone would be supported if an experimental increase of GIP concentrations were evident post-surgery. Given that, on the contrary, collected evidence suggests that GIP concentrations decrease post-surgery, the lower-intestinal dumping hypothesis would seem to describe the mechanism most likely to produce the observed normalization of Type 2 Diabetes Mellitus (T2DM) after bariatric surgery.The proposed model can help discriminate among competing hypotheses in a context where definitive data are not available and mechanisms are still not clear.
%K Bariatric Surgery
%K Diabetes
%K Mathematical Model
%K Incretins
%U http://www.tbiomed.com/content/9/1/16/abstract