%0 Journal Article
%T Association between Endoplasmic Reticulum Aminopeptidase-1 (ERAP-1) and Susceptibility to Ankylosing Spondylitis in Iran
%A Mahdi Mahmoudi
%A Ahmad Reza Jamshidi
%A Ali Akbar Amirzargar
%A Elham Farhadi
%J Iranian Journal Of Allergy, Asthma and Immunology
%D 2012
%I Tehran University of Medical Sciences
%X Ankylosing Spondylitis (AS) is an inflammatory arthritis, which affects mainly spine and sacroiliac joints. According to recent studies, ERAP1 is the second most common candidategene for AS susceptibility after HLA-B27. The aim of this study was to determine the association of ERAP1 gene polymorphisms with AS in Iranian population.The study group comprised 387 Iranian AS patients and 316 healthy controls from Iran.Using Real Time PCR allelic discrimination method, we genotyped four SNPs (rs30187,rs469876, rs13167972 and rs27434) of ERAP1.We found that rs30187 and rs27434 were significantly associated with AS in Iranian population (P=6กม10-5, P=7กม10-3, respectively). The rs30187 T/T genotype was associated with AS compared with C/C genotype (P=1.5กม10-5). The rs27434 G/G genotype was inversely associated with AS (P=5กม10-3). Two specific haplotypes including: rs30187/ rs469876/ rs13167972/ rs27434 TAAA and CAGG were associated with increased and decreased risk of AS in Iranian population, respectively.These results indicated that ERAP1 SNPs and haplotypes were associated with AS in Iranian population.
%K Ankylosing Spondylitis
%K Endoplasmic Reticulum Aminopeptidase-1
%K Single Nucleotide Polymorphism
%U http://ijaai.tums.ac.ir/index.php/ijaai/article/view/370/409