%0 Journal Article
%T Antinociceptive Effect of Promethazine in Mice
%A Amir Farshchi
%A Golbarg Ghiasi
%A Peyman Malek Khatabi
%A Hosein Farzaee
%J Iranian Journal of Basic Medical Sciences
%D 2009
%I Mashhad University of Medical Sciences
%X Objective(s)The present study was undertaken to investigate the nociception activity of promethazine, a tranquillizer devoid of hypnotic activity in mice.Materials and MethodsAntinociception was evaluated, using the acetic acid-induced writhing, tail flick, hot plate and formalin pain tests.ResultsPromethazine (4 and 6 mg/kg) and acetylsalicylic acid (100 mg/kg) produced a significant inhibition of the second phase response in the formalin pain model (P<0.05) and the drug couldn¡¯t show an antinociceptive effect in the first phase. Morphine (10 mg/kg) inhibited both first and second phase response (P<0.01). Drug also showed a dose-dependent inhibition of acetic acid-induced abdominal writhes. The tail flick and hot plate latency weren¡¯t different from control (P>0.05) and administration of naloxone (0.1 mg/kg) couldn't block the antinociceptive effect of promethazine.ConclusionThe data obtained suggest that antinociceptive effects of the promethazine may be mediated via peripheral and not central mechanisms.
%K Antinociceptive
%K Formalin test
%K Hot plate
%K Promethazine
%K Tail flick
%K Writhing test
%U http://www.mums.ac.ir/shares/basic_medical/basicmedjou/88/autumn/farshchi.pdf