%0 Journal Article
%T Vitamin E Derivative Alpha-Tocotrienol Failed to Show Neuroprotective Effects after Embolic Stroke in Rats
%A Mohammad Allahtavakoli
%A Aliasghar Pourshanazari
%A Behnam Heshmatian
%J Iranian Journal of Basic Medical Sciences
%D 2009
%I Mashhad University of Medical Sciences
%X Objective(s)Previous studies have demonstrated that pretreatment with alpha-tocotrienol (¦Á-TCT) can reduce ischemic damage in mice following middle cerebral artery (MCA) occlusion. It is also reported to decrease stroke-dependent brain tissue damage in 12-Lox-deficient mice and spontaneously hypertensive rats. In the present study, the neuroprotective effects of ¦Á-TCT and rosiglitazone (RGZ) at 3 hr after cerebral ischemia were investigated. Materials and MethodsStroke was induced by embolizing a preformed clot into the MCA. Rats were assigned to vehicle, ¦Á-TCT (1 or 10 mg/kg), RGZ and sham-operation. ResultsCompared to the control group, only RGZ decreased infarct volume (P<0.05), neurological deficits (P<0.05) and sensory impairments (P<0.01) but low and high doses of ¦Á-TCT did not show any significant neuroprotective effect. ConclusionOur data showed that ¦Á-TCT was not neuroprotective at 3 hr after the embolic model of stroke. Further studies should be undertaken to clarify the neuroprotective effects of ¦Á-TCT after stroke.
%K Alpha-tocotrienol
%K Cerebral ischemia
%K Embolic mod
%K Neuroprotection
%K Vitamin E
%U http://www.mums.ac.ir/shares/basic_medical/basicmedjou/88/spring/Allahtavakoli.pdf