%0 Journal Article
%T TGF-¦Â1 gene expression in skin lesions and correlation with pruritus in mustard gas exposed victims
%A Isa Khaheshi
%A Saeeid Keshavarz
%A Majid Shohrati
%A Abbasali Fooladi Imani
%J Dermatology and Cosmetic
%D 2010
%I 
%X "nBackground and Aim: As a blistering agent, mustard gas causes a variety of disorders in different body organs, including the skin, such as altrations in DNA and clinical manifestations like pruritus. TGF-¦Â1 molecule is a cytokine with anti-cell growth and inflammation suppression effects in skin inflammation. The aim of this study was to determine TGF-¦Â1 gene exprtession in victims exposed to mustard gas and the correlation with the severity of their pruritus."n"nMethods: 17 victims exposed to mustard gas, 17 patients with chronic contact dermatitis and 10 healthy individuals were included in the study. The assessment of TGF-¦Â1 expression in their skin samples was conducted by semi-quantitative RT-PCR followed by immunohistochemistry and classification of patients was done by pruritus severity scoring system (0-3)."n"nResults: There was a significant decrease in TGF-¦Â1 gene expression in mustard gas exposed victims comparing to chronic contact dermatitis group and the control group (P<0.05). In addition, in the absence of TGF-¦Â1 expression, the severity of pruritus in the patient group significantly increased (P<0.05)."n"nConclusion: TGF-¦Â1 has a significant role in chronic inflammatory skin lesions caused by mustard gas.
%K TGF-¦Â1
%K cytokine
%K mustard gas
%K pruritus
%U http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/18632.pdf&manuscript_id=18632