%0 Journal Article
%T Beyond NF-百B activation: nuclear functions of I百B kinase 汐
%A Huang Wei-Chien
%A Hung Mien-Chie
%J Journal of Biomedical Science
%D 2013
%I BioMed Central
%R 10.1186/1423-0127-20-3
%X I百B kinase (IKK) complex, the master kinase for NF-百B activation, contains two kinase subunits, IKK汐 and IKK汕. In addition to mediating NF-百B signaling by phosphorylating I百B proteins during inflammatory and immune responses, the activation of the IKK complex also responds to various stimuli to regulate diverse functions independently of NF-百B. Although these two kinases share structural and biochemical similarities, different sub-cellular localization and phosphorylation targets between IKK汐 and IKK汕 account for their distinct physiological and pathological roles. While IKK汕 is predominantly cytoplasmic, IKK汐 has been found to shuttle between the cytoplasm and the nucleus. The nuclear-specific roles of IKK汐 have brought increasing complexity to its biological function. This review highlights major advances in the studies of the nuclear functions of IKK汐 and the mechanisms of IKK汐 nuclear translocation. Understanding the nuclear activity is essential for targeting IKK汐 for therapeutics.
%K Nuclear IKK汐
%K NF-百B
%K Gene transcription
%K Tumor progression
%U http://www.jbiomedsci.com/content/20/1/3