%0 Journal Article
%T Suppression of humoral immune response to hepatitis B surface antigen vaccine in BALB/c mice by 1-methyl-tryptophan co-administration
%A T Eleftheriadis
%A T Sparopoulou
%A G Antoniadi
%A V Liakopoulos
%J DARU : Journal of Pharmaceutical Sciences
%D 2011
%I BioMed Central
%X Background and the purpose of the study:Indoleamine 2,3-dioxygenase (IDO) suppresses adaptive immune response. The purpose of this study was to determine the effect of the IDO inhibitor namely 1-methyl-DL-tryptophan (DL-1-MT) on antibody production after vaccination with hepatitis B surface (HBs) antigen. Methods:Four groups of BALB/c mice were immunized with a HBs antigen vaccine. In the first group the vaccine had no DL-1-MT, whereas in the other three groups the vaccine contained 1 mg , 10 mg and 20 mg DL-1-MT. Blood samples were collected 5 weeks post-vaccination and anti-HBs antibodies in the serum were measured by ELISA. Results:Compared to the three groups of mice that were immunized with the vaccines containing DL-1-MT, serum anti-HBs level was much higher in the mice that were immunized with the vaccine with out DL-1-MT. Conclusions:Inhibition of IDO at the time of vaccination decreased humoral immune response to HBs antigen vaccine. The idea that IDO activity is simply immunosuppressive may need to be re-evaluated.
%K DL-1-MT
%K IDO
%K Serum anti-HBs
%U http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/18773.pdf&manuscript_id=18773