%0 Journal Article
%T Design and evaluation of a new dry powder inhaler
%A "Rouholamini Najafabadi AH
%A Gilani K
%A Hozan AA "
%J DARU : Journal of Pharmaceutical Sciences
%D 2001
%I BioMed Central
%X Three versions of a new dry powder inhaler (DPI), RG-haler, were designed using two kinds of grid inserts. Salbutamol sulfate/lactose blend (Ventolin Rotacaps ) was selected as a model formulation to analyze the performance of all inhalers and compare their efficiency with three marketed devices (Rotahaler , Spinhaler  and ISF inhalator ) using the twin impinger (TI). Deposition of the drug in device was significantly (P<0.05) lower for ISF inhalator  and all kinds of RG-halers in comparison with those of Rotahaler  and Spinhaler . The amount of drug deposited in the stage 2 and the respirable dose for RG-halers were similar to those of ISF inhalator  and significantly (P<0.05) higher than those of Rotahaler  and Spinhaler . The results suggest efficient aerosol generating capability of the RG-haler.
%K Salbutamol sulfate
%K Twin impinger
%K Respirable fraction
%U http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/1294.pdf&amp;manuscript_id=1294