%0 Journal Article
%T Synthesis and antimycobacterial activity of 2-hydroxyacetamides
%A Fereidoon Daryaee
%A Farzad Kobarfard
%A Ali Khalaj
%A Parissa Farnia
%J DARU : Journal of Pharmaceutical Sciences
%D 2005
%I BioMed Central
%X On the basis of the structural similarity of 2-hydroxyacetamides (glycolamides) with N-glycolylmuramic acid residues of the cell wall of Mycobacterium tuberculosis several of these compounds were prepared mainly by the reaction of 5-oxo-2,2-dimethyl-1,3-dioxolane 1 (glycolic acid acetonide) with corresponding amines and their antimycobacterial activities were determined by Alamar blue Assay. Of the synthesized compounds disubstituted amides bearing hydrophilic moieties showed moderate activity.
%K "2-Hydroxyacetamides
%K Glycolic acid acetonide
%K Alamar blue Assay
%K Hydrophilicity"
%U http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/1664.pdf&manuscript_id=1664