%0 Journal Article
%T Calumenin and Reticulocalbin are Associated with the Protein Translocase of the Mammalian Endoplasmic Reticulum
%A Jens Tyedmers
%A Monika Lerner
%A Wolfgang Nastainczyk
%A Richard Zimmermann
%J Journal of Biological Sciences
%D 2005
%I Asian Network for Scientific Information
%X Transport of precursor proteins into the Endoplasmic Reticulum (ER) requires signal peptides in the precursor proteins and a protein translocase in the ER membrane. Recent findings about the protein translocase of the mammalian ER suggest that the membrane is permeable to small molecules during protein translocation/insertion. Since the ER also plays a central role in calcium homeostasis the question arises of how these two activities of the ER are reconciled. Here two EF-hand proteins of the ER were characterized as associates of protein translocase. A model for the activity of these proteins in protein transport and calcium homeostasis is proposed.
%U http://docsdrive.com/pdfs/ansinet/jbs/2005/70-75.pdf