%0 Journal Article
%T DNA-Harmalol interaction: The effects of Harmalol on the solution structure of calf-thymus DNA studied by FTIR spectroscopy
%A Hadji Akhoondi A
%A Nafisi Sh
%A Diari H
%J DARU : Journal of Pharmaceutical Sciences
%D 2000
%I BioMed Central
%X The interaction of hamalol with calf-thymus DNA was investigated at physiological pH with drug/DNA (phosphate) molar ratio(r) of 1/40. Fourier transform infrared difference spectroscopy were used to establish correlations between spectral changes and drug binding mode, sequence selectivity, DNA conformation and structural properties of harmalol-DNA complexes in aqueous solution. Spectroscopic results indicated that harmalol is a weak intercalator with affinity for A-T rich regions. At low drug concentration (r=1/40), the A-T region is the main target of drug intercalation.
%K Calf-thymus DNA
%K Harmalol
%K FTIR
%U http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/1324.pdf&manuscript_id=1324