%0 Journal Article
%T BIOCHEMICAL AND SEROLOGICAL PROFILING OF SANDHI SHOOLA (ARTHRALGIA) PATIENTS OF AYURVEDA HOSPITAL
%A Amit Kumar Dixit
%A Ranjit Kumar Dey
%A Ashok Kumar Panda
%A Achintya Mitra
%J International Journal of Research in Ayurveda and Pharmacy
%D 2013
%I International Journal of Research in Ayurveda and Pharmacy
%R 10.7897/2277-4343.04210
%X Sandhi shoola refers to the joints pain where there is pain with or without inflammation and can be caused by injury or a number of autoimmune disorders such as rheumatoid arthritis and gout. Ayurveda system of medicine believes this as Sandhi shoola condition in which there is difficulty in walking and running and based on the physical examination, it is categorized into major types i.e. Aamvata (AV), Sandhivata (SV) and Vatarakta (VR). However, biochemical and serological investigations for Sandhi shoola were not cited in ancient Ayurveda literature. A retrospective study in which biochemical and serological investigations such as uric acid (UA), Ca2+ and rheumatoid arthritis factor (RAF), C-reactive protein (CRP), antistreptolysin-O (ASO) were carried out respectively in 50 Sandhi shoola patients of Ayurveda hospital in Kolkata. The individual information about clinical symptoms and diagnosis by the hospital professionals were recorded. UA and Ca2+ content in serum was determined by enzymatic and Cresolphthalein complexone kit methods respectively, however RAF, CRP and ASO were determined through latex agglutination method. Results showed that maximum number of patients (24) suffered from AV followed by SV (15) and VR (11). The range of the UA and Ca2+ were 2.6 ¨C 18.0 mg/dl and 7.0 ¨C 11.3 mg/dl respectively. The average UA content is maximum in case of VR, while no significant difference was found in Ca2+ content among the three Sandhi shoola. Serological tests indicated maximum RAF positive samples in case of AV followed by SV patients, while CRP was positive in maximum patients of AV and SV. Results revealed a strong diagnostic measure for Sandhi shoola and suggested that higher UA content and positive RAF should be a diagnostic measure in case of Vatarakta and Aamvata respectively. In conclusion, modern biochemical and serological investigations should be exercised in Ayurveda practice for diagnostic and validation with scientific justification strengthening the Ayruvedic principles.
%K Arthralgia
%K rheumatoid arthritis factor
%K C-reactive protein
%K uric acid.
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