%0 Journal Article
%T "Pharmacodynamically evaluated bioequivalence of two preparations of Enalapril Maleate "
%A "Tajerzadeh H
%A Hamidi M
%A Rouini MR
%A Shahverdi M
%J DARU : Journal of Pharmaceutical Sciences
%D 2001
%I BioMed Central
%X The bioequivalence of two preparations of enalapril maleate (20 mg tablets) manufactured in Iran has been exploited in reference to a standard preparation (Xanef 20 tablets, MSD, Germany) in 14 healthy volunteers. Following oral dosing of a single tablet of each of test and standard products, as a randomized crossover design with 10-day washout intervals, the blood samples were collected in predetermined time points and using a synthetic substrate, Hippuryl-Histidy-Leucine (HHL), the release of hippuric acid from the substrate was determined as Angiotensin-Converting-Enzyme (ACE) activity of serum fractions. The percent of ACE inhibition in each sample was calculated and plotted against time, from which three pharmacodynamic parameters, i.e. Emax, tmax and AUC0-24 were derived. The results of statistical comparison of these parameters showed that both of the test preparations are bioequivalent with reference standard preparation.
%K Enalapril maleate
%K ACE
%K ACE inhibitors
%K Clinical study
%U http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/1280.pdf&manuscript_id=1280