%0 Journal Article
%T Inhibitory effect of dates-extract on ¦Á-Amylase and ¦Â-glucosidase enzymes relevant to non-insulin dependent diabetes mellitus
%A Sulaiman Al-Zuhair
%A Ali Dowaidar
%A Hassan Kamal
%J Journal of Biochemical Technology
%D 2010
%I Sevas Publication
%X ¦Á-Amylase and ¦Á-glucosidase are key enzymes involved incarbohydrates breakdown and intestinal absorption, respectively.Inhibition of these enzymes hinders blood glucose level increaseafter a carbohydrate diet and can be an important strategy in themanagement of non-insulin-dependent diabetes mellitus (NIDDM).A main drawback of currently used inhibitors is their side effectssuch as abdominal distention, flatulence, meteorism and diarrhea,caused by excessive inhibition of pancreatic ¦Á-amylase resulting inabnormal bacterial fermentation of undigested carbohydrates in thecolon. Natural inhibitors from plants have shown lower inhibitoryeffect against ¦Á-amylase activity and a stronger inhibitory activityagainst ¦Á-glucosidase and can be used as effective therapy forNIDDM with minimal side effects. In this work dates-extract (DE)inhibitory effect on ¦Á-amylase and ¦Á-glucosidase has been assessed.The inhibition percentages on ¦Á-amylase and ¦Á-glucosidase were inthe range of 6-24% and 54%, respectively. The results clearly showthe NIDDM treatment potential of DE.
%K Diabetes
%K dates-extract
%K ¦Á-amylase
%K ¦Á-glucosidase
%K enzyme inhibition
%U http://www.jbiochemtech.com/index.php/jbt/article/view/61