%0 Journal Article
%T Conformational Analysis of Some Novel Aurone Analogs of DHA as Tyrosine Kinase Receptor Inhibitors
%A Girish Kumar Gupta and Vinod Kumar
%J Current Trends in Biotechnology and Chemical Research
%D 2013
%I M.M.University Mullana, Ambala
%X Aurones are heterocyclic compounds that belong to a class of flavonoids which exhibit a wide spectrum of biological activities. They can exist in two geometrical isomeric forms i.e. E and Z but generally, exist in Z- form because of more stability. So far, various kinds of aurone derivatives starting from differently substituted acetophenones through the intermediacy of chalcone derivatives have been reported in literature and were also evaluated for their different types of biological activities. However, aurone analoges starting from dehydroacetic acid (DHA) have not been explored well synthetically as well as biologically. In the present manuscript, conformational analysis of the aurone analogue of DHA was performed according to the Hartree-Fock (HF) calculation method by Argus lab 4.0.1 software. The minimum potential energy was calculated by geometry convergence function by Argus lab software. It has been found that the most feasible position for the 2-arylidene- 6-methylfurano[4,3-b]pyran-3H, 4H-dione to interact with the receptor possesses -1.13687 K.cal/mole. Further on the basis of results obtained it is concluded that they act as fibroblast growth factor receptor inhibitors (FGFRs inhibitors) or tyrosine kinase receptor inhibitors.
%U http://ctbcr.com/index.php/biochem/article/view/57