%0 Journal Article
%T SYNTHESIS AND BIOLOGICAL ACTIVITIES OF CERTAIN MESOIONIC SYDNONE COMPOUNDS CONTAINING CHALCONE MOIETY
%A Shreenivas R. Deshpande
%A K. Vasantakumar Pai
%J Journal of Basic and Clinical Pharmacy
%D 2010
%I 
%X In order to have antibacterial, analgesic and anti-inflammatory activity in the same molecule, 4-[1-oxo-3- (substituted aryl)-2-propenyl]-3-(4-chlorophenyl)sydnones were synthesized by condensing 4-acetyl-3-(4-chlorophenyl)sydnone with various substituted aryl aldehydes and characterized by spectral studies; 4-acetyl-3-(4-chlorophenyl)sydnone itself, was prepared by acetylation of 3-(4-chlorophenyl)sydnone. The newly synthesized compounds were evaluated for antibacterial and anti-inflammatory activities by cup plate and carrageenan induced rat paw edema methods respectively. Some of the compounds showed promising antibacterial and anti-inflammatory activities.
%K Synthesis
%K sydnone
%K chalcone
%K antibacterial
%K anti-inflammatory
%U http://www.jbclinpharm.com/Volume1Issue3Articles/HTML/HTML02_V1_I3.aspx