%0 Journal Article
%T Low Zip 4 gene expression levels in RPMI - 8226 and ARH - 77 cell lines support the possible role of zip 4 transporter protein in plasma cell tumorogenesis
%A £¿efik G¨¹ran
%A Zehra Dil£¿ad £¿oban
%A Deniz Torun
%A Ferit Avcu
%J Cumhuriyet Medical Journal
%D 2013
%I Cumhuriyet University School of Medicine
%X Aim. Multiple myeloma and plasma cell leukemia are cancers of plasma cells. Multiple myeloma rarely transforms to plasma cell leukemia during the progression period. Zinc as a chemical element modulates proliferation and differentiation of cells by affecting several growth factors. Zip 4 modifies zinc metabolism in a cell as a transporter protein. While high Zip 4 gene expression was found in pancreas and hepatocellular carcinoma, low Zip 4 gene expression was observed in prostate carcinoma. Methods. Here, Zip 4 expression levels were studied in RPMI - 8226 and ARH - 77 cell lines as examples of multiple myeloma and plasma cell leukemia, respectively. Results. We found lower Zip 4 gene expression levels in both cell lines than that of the normal control (0,000157 in RPMI - 8226, 0,000227 in ARH - 77 cell lines and 1 in normal control) The findings were statistically significant (P < 0.05). The expression levels of Zip 4 gene in both cell lines were approximately similar. No statistical significance was found between the expression levels of Zip 4 in both cell lines (P = 0.547). Conclusion. The results of this study support the possible role of Zip 4 gene expression in plasma cell dyscrasias. The similar result of Zip 4 gene expression level in both cell lines may show that Zip 4 has no role in the transformation of multiple myeloma to plasma cell leukemia.
%K Zip 4 gene
%K Gene expression
%K Multiple myeloma
%K Plasma cell leukemia
%U http://dergi.cumhuriyet.edu.tr/ojs/index.php/tipdergisi/article/view/1705/1671