%0 Journal Article
%T Thermal investigation of Human Serum Albumin upon Interaction with Ytterbium (III)
%A Mohammad Mirzaie
%A Lyla Barzegar
%A Gholamreza Rezaei Behbehani
%A Ali Akbar Saboury
%J Current Chemistry Letters
%D 2012
%I Growing Science
%X In this paper complexation reaction between Yb3+ and Human serum albumin is examined using isothermal titration calorimetry (ITC). The extended solvation model was used to reproduce the enthalpies of HAS+Yb3+ interactions over the whole range of Yb3+ concentrations. The binding parameters recovered from this model were attributed to the structural change of HSA. The results show that Yb3+ ions bind to HSA with three equivalent affinity sites. It was found that in the high concentrations of the ytterbium ions, the HSA structure was destabilized.
%K Isothermal Titration Calorimetry
%K Human Serum
%K Yb3+ Ion
%K Binding Parameters
%U http://www.growingscience.com/ccl/Vol1/ccl_2012_5.pdf