%0 Journal Article
%T Hypocholestrolemic and Antioxidant Activities of Dikanut (Irvingia gabonensis) Supplemented Diet in Abino Rats
%A Friday O. Uhegbu
%A Kingsley C. Nwoku
%A Victor C. Ude
%J Current Research Journal of Biological Sciences
%D 2013
%I Maxwell Science Publication
%X Hypocholesterolemic and Antioxidant activities of Dikanut (Irvingia gabonensis) supplemented diet in Abino rats was investigated. Albino rats (males) were fed diets `supplemented with 10, 20 and 30%, respectively dikanut for 14 days. Results showed significant (p<0.05) reductions in cholesterol levels compared to control; 1.43¡À0.08 to 0.88¡À0.10 mg/mL in the test animals. Lipid peroxidation levels also decreased significantly (p<0.05) from 6.56¡À0.23 mg/mL for control to 4.16¡À0.48 mg/mL for the test animals, while antioxidant enzymes (SOD and Catalase) levels increased significantly (p<0.05) compared to control, 21.30¡À3.28 to 28.72¡À3.68 and 2.26¡À0.05 to 2.95¡À0.11 U/L, respectively. Glutathione peroxidase level also showed significant (p<0.05) reductions from 3.82¡À0.41 U/L for control to 3.06¡À0.62 U/L in the test animals. The elicitation of these effects by the dikanut supplemented diet is a reflection of its hypocholesterolemic and antioxidative properties and could be of nutritional and clinical importance to persons at risk of cardiovascular disease.
%K Cardiovascular disorders
%K cholesterol
%K free radicals
%K lipid
%K oxidative stress
%U http://www.maxwellsci.com/jp/abstract.php?jid=CRJBS&no=292&abs=04