%0 Journal Article
%T DETERMINATION OF TELMISARTAN IN PHARMACEUTICAL FORMULATIONS BY REVERSE PHASE-HIGH PERFORMANCE LIQUID CHROMATOGRAPHY
%A Manoj S. Charde
%A A. Gupta
%A R. D. Chakole
%J International Journal of Phytopharmacy
%D 2012
%I Scholar Science Journals
%R 10.7439/ijpp.v2i2.440
%X A simple, sensitive and reproducible reverse-phase high performance liquid chromatographic (RP-HPLC) method has been developed for the quantitative estimation of Telmisartan (TELM) in the pharmaceutical formulations. Chromatographic separation was achieved on a 250  ¡ª 4.6 mm, 5  , Waters symmetry column. The flow rate was 1 ml/min and eluent was monitored by absorbance at 230 nm using a mixture of Methanol and Acetonitrile (pH 3.0 ¡À0.01) in the ratio of 30:70 (v/v). The retention time of Telmisartan was found to be 7.9 min. Calibration plots were linear in the concentration range of 10-50   g/ml for Telmisartan with correlation coefficient (R2) 0.999. The proposed method was validated by testing its linearity, recovery, specificity, system suitability, precision (Interday, intraday, analyst and instrument precision), robustness and LOD/LOQ values and it was successfully employed for the determination of Telmisartan in pharmaceutical tablet formulations.
%K HPLC
%K Acetonitrile
%K Telmisartan
%K Validation
%U http://ijpp.ssjournals.com/index.php/journal/article/view/18