%0 Journal Article
%T Psorospermum Febrifugum Spach (Hypericaceae) Decoction Antagonized Chemically-induced Convulsions in Mice
%A E. Ngo Bum
%A Y.F.C. Naami
%A S. Soudi
%A S.V. Rakotonirina
%J International Journal of Pharmacology
%D 2005
%I Asian Network for Scientific Information
%X Psorospermum febrifugum Spach is used in traditional medicine in Cameroon to treat epilepsy. The decoction of Psorospermum febrifugum slightly increased the total sleep time induced by diazepam (50 mg kg-1 i.p.). It   also  protected mice against pentylene tetrazol-, picrotoxin-and strychnine-induced seizures. Dose 300 mg kg-1 provided 83.3% of protection against pentylene tetrazol-induced clonic convulsions (the same protection as clonazepam 0.1 mg kg-1). For the strychnine test, Psorospermum febrifugum protected 66.7% of mice at a dose of 1000 mg kg-1. 83.3% of mice were protected against picrotoxin-induced seizures at a dose of 3000 mg kg-1. The antagonism of chemically-induced seizures suggests that Psorospermum febrifugum decoction possesses anticonvulsant properties in mice.
%U http://docsdrive.com/pdfs/ansinet/ijp/2005/118-121.pdf