%0 Journal Article
%T COMPARATIVE EVALUATION OF EXTRACTS OF C. IGNEUS (OR C. PICTUS) FOR HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITY IN ALLOXAN DIABETIC RATS.
%A Abdul Bakrudeen Ali Ahmed2*
%J International Journal of Pharmacy and Technology
%D 2010
%I IJPT
%X Aims: To compare the possible therapeutic effects of C. igneus methanolic and aqueous extractsagainst hyperglycemic and hyperlipidemic activity in alloxan induced diabetic rats.Materials and Methods: Blood glucose level, serum lipid profile and pancreas histology as well as phytochemical investigations were estimated after administration of the both extracts at dose level of50, 100 and 200 mg/kg were comparable to that of glibenclamide (0.5mg/kg).Result: All studies in aqueous and methanolic extracts of Costus igneus have shown better effect on end of 30th day. The significantly reduce type 2 diabetes in rats and regulation of insulin secretion,islet protection as well as produce higher antidiabetic compounds by methanolic extract at dose level of 200 mg/kg.Conclusion: Our results suggest that the Costus igneus methanolic extract anti-diabetic activity is slightly higher to the aqueous extract and good agreement with the folk medicinal use of this plant.
%K Costus igneus
%K Flavonoids
%K Glibenclamide
%K Hypolipidaemic
%K Hypoglycemic.
%U http://www.ijptonline.com/wp-content/uploads/2009/10/183-195.pdf