%0 Journal Article
%T Effect of ¦Â2-adrenergic receptor gene (ADRB2) 3¡ä untranslated region polymorphisms on inhaled corticosteroid/long-acting ¦Â2-adrenergic agonist response
%A Helen J Ambrose
%A Rachael M Lawrance
%A Carl J Cresswell
%A Mitchell Goldman
%A Deborah A Meyers
%A Eugene R Bleecker
%J Respiratory Research
%D 2012
%I BioMed Central
%R 10.1186/1465-9921-13-37
%X In 2,250 asthma patients randomized to treatment with budesonide/formoterol or fluticasone/salmeterol in a six-month study (AstraZeneca study code: SD-039-0735), sequence diversity in the ADRB2 poly-C repeat region was determined using a novel sequencing-based genotyping method. The relationship between the poly-C repeat polymorphism and the incidence of severe asthma exacerbations, and changes in pulmonary function and asthma symptoms from baseline to the average during the treatment period, were analyzed.Poly-C repeat genotypes were assigned in 97% (2,192/2,250) of patients. Of the 13 different poly-C repeat alleles identified, six alleles occurred at a frequency of >5% in one or more population in this study. The repeat length of these six common alleles ranged from 10 to 14 nucleotides. Twelve poly-C repeat genotypes were observed at a frequency of >1%. No evidence of an association between poly-C repeat genotype and the incidence of severe asthma exacerbations was observed. Patients¡¯ pulmonary function measurements improved and asthma symptoms declined when treated with ICS/LABA combination therapy regardless of poly-C repeat genotype.The extensive sequence diversity present in the poly-C repeat region of the ADRB2 3¡äUTR did not predict therapeutic response to ICS/LABA therapy.
%K Asthma
%K ¦Â2-agonist
%K Inhaled corticosteroid
%K Genotype
%K Polymorphism
%K ¦Â2-adrenergic receptor
%K 3¡ä untranslated region
%K Poly-C repeat
%U http://respiratory-research.com/content/13/1/37/abstract