%0 Journal Article
%T A Comparison of the Sensory and Motor Blockade Duration of Intrathecal Lidocaine 5%, Lidocaine 5% Plus Epinephrine and Lidocaine 5% Plus Dexamthasone: A Double Blind Randomized Clinical Trials Study
%A Ali Movafegh
%A Mohamad Hussein Ghafari
%J International Journal of Pharmacology
%D 2005
%I Asian Network for Scientific Information
%X In the present study we conducted a randomized, prospective, double-blind, placebo-controlled clinical trial to evaluate the prolongation of lidocaine spinal anesthesia by intrathecal administration of dexamethasone. Ninety male patients scheduled for orthopedic surgery under spinal anesthesia were enrolled in the study and were randomly allocated to one of three groups and received their treatments intrathecaly; Group 1: 75 mg 5% lidocaine + 2 mL 0.9% NaCl; Group 2: 75 mg 5% lidocaine + 0.2 mg epinephrine (0.2 mL-BP) +1.8 mL 0.9% NaCl and Group 3: 75 mg 5% lidocaine + 8 mg dexamethasone (2 mL-BP). After performance of the block patients were kept in supine position and the pinprick level were kept between T6 to T8 in all patients. Block regression was estimated by pinprick every 5 min until a 4 sensory level regression from highest level. The duration of motor block was the time needed until the block returned to level 0 from level 3 on the Bromage scale. There were no significant differences in demographic data, duration of surgery, ASA classes (I/II), the maximal cephaled level and onset time of sensory and motor block among the groups. The duration of sensory block was significantly longer in the lidocaine-epinephrine and lidocaine-dexamthasone groups than the lidocaine group (respectively 85.7 and 82.1 min vs. 55.9 min for sensory block and 112.8 and 118.9 min vs. 79.2 min for motor block, p<0.001). The incidence of complications and the need for treatments were not different among groups. After one month follow up, no neurological or infectioneuos disorder was found in patients. We have shown that the addition of dexamethasone (8 mg-BP) intrathecaly to lidocaine spinal anesthesia prolongs the duration of intrathecal lidocaine sensory and motor blocks.
%U http://docsdrive.com/pdfs/ansinet/ijp/2005/346-349.pdf