%0 Journal Article
%T FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF CARBAMAZEPINE BY SOLID DISPERSION METHOD
%A N. G. Raghavendra Rao1*
%J International Journal of Pharmacy and Technology
%D 2010
%I IJPT
%X An attempt has been made for the development of fast dissolving tablets of the carbamazepine by solid dispersion methods, using different concentrations of croscarmellose sodium as superdisintegrating agent. The major problem of this drug is very low solubility in biological fluids and poor bioavailability after oral administration. The tablets prepared were evaluated for hardness, friability,drug content, disintegrating time, wetting time and in-vitro dissolution studies. The formulations prepared with mannitol solid dispersion were showed disintegration time between the ranges of 12.83 ¨C16.79 sec and Drug release showed between the ranges of 08 ¨C 10 min. However the formulations prepared with PEG-6000 solid dispersion did not disintegrate in specified limit of time for fastdissolving tablet. Among all formulations SM4 showed 99.50 % drug release within 8 minutes. The prepared tablets were characterized by DSC and FTIR Studies. No chemical interaction between drug and excipient was confirmed by DSC and FTIR studies. The stability study conducted as per the ICH guidelines and the formulations were found to be stable. The results concluded that fast dissolving tablets of poorly soluble drug, carbamazepine showing enhanced dissolution, improved bioavailability,effective therapy and hence better patient compliance.
%K Fast dissolving tablets
%K carbamazepine
%K croscarmellose sodium
%K and solid dispersion.
%U http://www.ijptonline.com/wp-content/uploads/2009/10/23-37.pdf