%0 Journal Article
%T The Anti-inflammatory Activity of the Foeniculum vulgare L. Essential Oil and Investigation of its Median Lethal Dose in Rats and Mice
%A Hanefi Ozbek
%J International Journal of Pharmacology
%D 2005
%I Asian Network for Scientific Information
%X The aim of this study was to gas chromatographic analysis of extract of Foeniculum vulgare L. essential oil and to investigate its median lethal dose (LD50) and possible anti-inflammatory effects. The composition of the essential oil was as follows: 74.8% (E)-anethole, 11.1% limonene, 4.7% methyl chavicol, 2.5% fenchone and 1.3% ¦Á-pinene. The LD50 dose was found to be 1.038 mL kg-1. The essential oil of Foeniculum vulgare L. was investigated the model of carrageenan induced rat paw edema and it had an anti-inflammatory effect matching to that of etodolac at 0.050 and 0.200 mL kg-1 doses.
%U http://docsdrive.com/pdfs/ansinet/ijp/2005/329-331.pdf