%0 Journal Article
%T DETERMINATION OF MEXILETINE IN PHARMACEUTICAL PREPARATIONS BY ZERO-, FIRST- AND SECOND-ORDER DERIVATIVE SPECTROPHOTOMETRIC METHODS
%A B. Yilmaz*
%J International Journal of Pharmacy and Technology
%D 2010
%I IJPT
%X Mexiletine is an orally effective agent useful in the treatment of serious ventricular arrhythmias. This paper describes zero-, first- and second-order derivative spectrophotometric methods for determination of mexiletine in pharmaceutical preparations. The solutions of the standard and pharmaceutical samples were prepared in acetonitrile. Absorbances of mexiletine were measured at 262 nm for zero-order by measuring height of peak from zero, at 260, 268 and 274 nm for first and 272 and 277 for second-order derivative spectrophotometric method by measuring peak to peak height. The linearity ranges were found to be 20-140 ¦Ìg mL-1 for the zero, first- and second-order derivative spectrophotometric methods. The developed methods in this study are accurate, sensitive,precise, and reproducible and can be directly and easily applied to the pharmaceutical preparation. Also, the results obtained from three derivative spectrophotometric methods were compared and no significant difference was found statistically.
%K Mexiletine
%K Zero-
%K First-
%K Second-order Derivative Spectrophotometric Method
%K Pharmaceutical Preparation.
%U http://www.ijptonline.com/wp-content/uploads/2009/10/66-78.pdf