%0 Journal Article
%T A FACTORIAL STUDY ON FORMULATION DEVELOPMENT OF EFAVIRENZ TABLETS EMPLOYING 弛 CYCLODEXTRINPOLOXAMER 407- PVP K30
%A K.P.R. Chowdary
%J International Journal of Pharmaceutical Sciences and Research
%D 2012
%I Society of Pharmaceutical Sciences and Research
%X Efavirenz, a widely prescribed anti retroviral drug belongs to class I扣 under BCS and exhibit low and variable oral bioavailability due to its poor aqueous solubility. Its oral absorption is dissolution rate limited and it requires enhancement in the solubility and dissolution rate for increasing its oral bioavailability. The objective of the study is to evaluate the feasibility of formulating efavirenz 每汕CD每 Poloxamer 407 /PVP K30 inclusion complexes into tablets and to evaluate the effects of 汕CD, Poloxamer 407 and PVP K30 on the dissolution rate and dissolution efficiency of efavirenz tablets in 23 factorial study. A comparative evaluation of wet granulation and direct compression methods was made for the preparation of tablets employing drug 每 汕CD 每 Poloxamer 407 / PVP K30 inclusion complexes. Drug 每 汕CD- Poloxamer 407 / PVP K30 inclusion complexes were prepared by kneading method. Tablets each containing 100 mg of efavirenz were prepared by wet granulation and direct compression methods employing various 汕CD complexes as per 23 factorial design and the tablets were evaluated for dissolution rate and other physical properties. Efavirenz tablets formulated employing dug 每 汕CD 每 Poloxamer 407 / PVP K30 inclusion complexes and prepared by direct compression method disintegrated rapidly when compared to those made by wet granulation method. Efavirenz dissolution was rapid and higher from the tablets formulated employing drug- 汕CD- Poloxamer 407/ PVP K30 inclusion complexes when compared to the tablets containing efavirenz alone in both wet granulation and direct compression methods. The individual as well as combined effects of the three factors involved i.e., 汕CD ( factor A), Poloxamer 407 ( factor B) and PVP K30 ( factor C) were highly significant (P< 0.01) in enhancing the dissolution rate (K1) and dissolution efficiency (DE 30) of efavirenz in both wet granulation and direct compression methods. Among the three factors Poloxamer 407 (factor B) gave highest enhancement in the dissolution rate (K1) and dissolution efficiency (DE 30) of efavirenz tablets in both wet granulation and direct compression methods. 汕CD alone gave low dissolution rates in both wet granulation and direct compression methods. Combination of 汕CD with Poloxamer 407 or PVP K30 gave a significantly higher dissolution rate (K1) of efavirenz in both wet granulation and direct compression methods. Overall direct compression method gave higher dissolution rates (K1) and dissolution efficiency (DE 30) values than the wet granulation method in all the cases. Hence Poloxamer 407 alone or
%K Efavirenz Tablets
%K 弛- Cyclodextrin
%K Poloxamer 407
%K PVP K30
%K Dissolution Rate
%U http://ijpsr.com/V3I3/16%20Vol.%203,%20Issue%203,%202012,%20IJPSR-1070,%20Paper%2016.pdf